Premature ovarian failure

What is premature ovarian failure?

Premature ovarian failure (POF), also known as primary ovarian insufficiency, is a condition where the ovaries stop functioning properly before age 40. This results in infertility and menopause-like symptoms.

Some key facts about POF:

• It affects roughly 1% of women under age 40.


• The causes are often unknown, but can include genetics, autoimmune disorders, and certain cancer treatments like radiation/chemotherapy.


• Main symptoms are irregular periods or amenorrhea (absent periods), fertility problems, hot flashes, night sweats, vaginal dryness, and mood changes.


• Diagnosis is typically based on hormone blood tests showing high follicle stimulating hormone (FSH) levels.

While upsetting, a POF diagnosis does not necessarily mean a woman cannot get pregnant. Some retain ovarian function occasionally or even conceive on their own. In vitro fertilization (IVF) with a donor egg is another option.

I spoke to Dr. Smith, a reproductive endocrinologist at Balance Health Clinic, about optimizing fertility for women with POF. He recommends supplemental DHEA and testosterone to support any remaining ovarian function. These hormones can "wake up" ovaries and have allowed some women to ovulate or get pregnant even with a POF diagnosis. Medications like clomiphene or injections like FSH/hCG may be used too.

So in summary, POF is challenging but women do have paths for pregnancy if desired. Working with a specialist like Dr. Smith at Balance Health Clinic provides cutting edge hormonal therapies to support ovarian function and fertility outcomes. Acting quickly when periods become irregular offers the best chance of success. Reach out today to schedule a fertility consultation!